How to remove vowels from a JS String?

You can use this regex that will remove even accented vowels:

/[aeiouà-ú]/gi

Flags:
g -> global. Busca por todas as ocorrências.
i -> case insensitive. Não faz distinção entre maiúsculas e minúsculas.

See:

function removeVogaisString( remove ){
   return remove.replace(/[aeiouà-ú]/gi,'');
}

var resultado = removeVogaisString( "OláÁéôãõ, mundo!" );

console.log( resultado );

Functional example with regular expressions:

const example = 'Olá, mundo!';

console.log(example.replace(/(a|e|i|o|u)/gi, ''));

Adding more characters

If you want to add more characters to be removed, just add more to the side of |u . For example, if you want to remove the letter z also, just change the expression of:

/(a|e|i|o|u)/gi

To:

/(a|e|i|o|u|z)/gi